Role of p53 circuitry in tumorigenesis: a brief review

Niazi, Sarfaraj and Purohit, Madhusudan and Kolkar, Javed (2018) Role of p53 circuitry in tumorigenesis: a brief review. European Journal of Medicinal Chemistry, 158 . pp. 7-24. ISSN 0223-5234 (Print) 1768-3254 (Online)

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Maintenance of genome integrity under the stressed condition is paramount for normal functioning of cells in the multicellular organisms. Cells are programmed to protect their genome through specialized adaptive mechanisms which will help decide their fate under stressed conditions. These mechanisms are the outcome of activation of the intricate circuitries that are regulated by the p53 master protein. In this paper, we provided a comprehensive review on p53, p53 homologues and their isoforms, including a description about the ubiquitin-proteasome system emphasizing its role in p53 regulation. p53 induced E3(Ub)-ligases are an integral part of the ubiquitin-proteasome system. This review outlines the roles of important E3(Ub)-ligases and their splice variants in maintaining cellular p53 protein homeostasis. It also covers up-to-date and relevant information on small molecule Mdm2 inhibitors originated from different organizations. The review ends with a discussion on future prospects and investigation directives for the development of next-generation modulators as p53 therapeutics.
Item Type: Article
Uncontrolled Keywords: COP1; Mdm2; miRNA; Modulators; p53; Pharmacophore; Pirh2; Proteasome; Ubiquitin
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Javed Kolkar
Date Deposited: 31 Jul 2023 11:22
Last Modified: 31 Jul 2023 11:22

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