Kaushik, Aman Chandra and Kumar, Ajay and Bharadwaj, Shiv Kumar and Chaudhary, Ravi and Sahi, Shakti (2018) Three-dimensional (3D) pharmacophore modelling-based drug designing by computational technique. In: Kaushik, Aman Chandra and Kumar, Ajay and Bharadwaj, Shiv and Chaudhary, Ravi and Sahi, Shakti, (eds.) Bioinformatics Techniques for Drug Discovery: Applications for Complex Diseases. SpringerBriefs in Computer Science. Springer Cham, pp. 27-31. ISBN 978-3-319-75731-5 (Print) 978-3-319-75732-2 (Online)
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Official URL: https://dx.doi.org/10.1007/978-3-319-75732-2_4
Abstract
Three-dimensional (3D) pharmacophore modelling is a modern approach used to elucidate the intermolecular interaction of ligands with the target of interest. In the past few years, pharmacophore models have been developed with chemical features and are intuitively understandable and broadly employed successfully in computational drug discovery by the researchers. The concert and utility of pharmacophore modelling are demarcated by the two major factors; (i) definition and placement of pharmacophoric features and (ii) the arrangement approaches used to overlay the 3D pharmacophore models and small molecules. This chapter provides a brief account of the recent technologies and developed model used in pharmacophores-based drug design.
Item Type: | Book Section / Chapter |
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Uncontrolled Keywords: | 3D pharmacophore; Computational drug discovery; Modelling; Pharmacophore models |
Divisions: | Sabancı University Nanotechnology Research and Application Center |
Depositing User: | Shiv Kumar Bharadwaj |
Date Deposited: | 30 Jul 2023 23:05 |
Last Modified: | 30 Jul 2023 23:05 |
URI: | https://research.sabanciuniv.edu/id/eprint/46585 |