Curcumin delivery mediated by bio-based nanoparticles: a review

Nasery, Mahshid Moballegh and Abadi, Banafshe and Poormoghadam, Delaram and Zarrabi, Ali and Keyhanvar, Peyman and Khanbabaei, Hashem and Ashrafizadeh, Milad and Mohammadinejad, Reza and Tavakol, Shima and Sethi, Gautam (2020) Curcumin delivery mediated by bio-based nanoparticles: a review. Molecules, 25 (3). ISSN 1420-3049

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Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such as cancers, a number of them have displayed issues associated with their solubility, bioavailability, and bio-degradability. In the present review, we focus on curcumin, an important and widely used polyphenol, with diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic, anti-viral, etc. Notwithstanding, it also exhibits poor solubility and bioavailability that may compromise its clinical application to a great extent. Therefore, the manipulation and encapsulation of curcumin into a nanocarrier formulation can overcome these major drawbacks and potentially may lead to a far superior therapeutic efficacy. Among different types of nanocarriers, biological and biopolymer carriers have attracted a significant attention due to their pleiotropic features. Thus, in the present review, the potential protective and therapeutic applications of curcumin, as well as different types of bio-nanocarriers, which can be used to deliver curcumin effectively to the different target sites will be discussed.
Item Type: Article
Uncontrolled Keywords: Biopolymer; Cancer; Curcumin; Exosomes; Nanocarriers
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 29 Jul 2023 21:15
Last Modified: 29 Jul 2023 21:15

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