Autophagy as a cellular stress response mechanism in the nervous system

Peker, Nesibe and Gözüaçık, Devrim (2020) Autophagy as a cellular stress response mechanism in the nervous system. Journal of Molecular Biology, 432 (8). pp. 2560-2588. ISSN 0022-2836 (Print) 1089-8638 (Online)

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Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is one of the mechanisms that supports cell survival under stressful conditions. Autophagic vesicle engulfs the cargo and transports it to lysosome for degradation and turnover. As such, autophagy eliminates abnormal proteins, clears damaged organelles, limits oxidative stress and helps to improve metabolic balance. Nervous system cells and particularly postmitotic neurons are highly sensitive to a spectrum of insults, and autophagy emerges as one of the key stress response mechanism, ensuring health and survival of these vulnerable cell types. In this review, we will overview mechanisms through which cells cope with stress, and how these stress responses regulate autophagy, with a special focus on the nervous system.
Item Type: Article
Uncontrolled Keywords: autophagy; cellular stress; nervous system; neurodegenerative disease; neuron
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Devrim Gözüaçık
Date Deposited: 29 Jul 2023 20:05
Last Modified: 29 Jul 2023 20:05

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