Aptamer and nanomaterial based FRET biosensors: a review on recent advances (2014-2019)

Pehlivan, Zeki Semih and Torabfam, Milad and Kurt, Hasan and Ow-Yang, Cleva W. and Hildebrandt, Niko and Yüce, Meral (2019) Aptamer and nanomaterial based FRET biosensors: a review on recent advances (2014-2019). Microchimica Acta, 186 (8). ISSN 0026-3672 (Print) 1436-5073 (Online)

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Fluorescence resonance energy transfer, one of the most powerful phenomena for elucidating molecular interactions, has been extensively utilized as a biosensing tool to provide accurate information at the nanoscale. Numerous aptamer- and nanomaterial-based FRET bioassays has been developed for detection of a large variety of molecules. Affinity probes are widely used in biosensors, in which aptamers have emerged as advantageous biorecognition elements, due to their chemical and structural stability. Similarly, optically active nanomaterials offer significant advantages over conventional organic dyes, such as superior photophysical properties, large surface-to-volume ratios, photostability, and longer shelf life. In this report (with 175 references), the use of aptamer-modified nanomaterials as FRET couples is reviewed: quantum dots, upconverting nanoparticles, graphene, reduced graphene oxide, gold nanoparticles, molybdenum disulfide, graphene quantum dots, carbon dots, and metal-organic frameworks. Tabulated summaries provide the reader with useful information on the current state of research in the field.
Item Type: Article
Uncontrolled Keywords: Biosensors; Carbon dots; FRET; Gold nanoparticles; Graphene; Graphene quantum dots; Metal-organic framework; Quantum dots; Reduced graphene oxide; ssDNA; Up-converting nanoparticles
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Cleva W. Ow-Yang
Date Deposited: 24 Jul 2023 21:16
Last Modified: 24 Jul 2023 21:16
URI: https://research.sabanciuniv.edu/id/eprint/46238

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