Design and bioprinting for tissue interfaces

Altunbek, Mine and Afghah, Ferdows and Çalışkan, Özüm Şehnaz and Yoo, James J. and Koç, Bahattin (2023) Design and bioprinting for tissue interfaces. Biofabrication, 15 (2). ISSN 1758-5082 (Print) 1758-5090 (Online)

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Tissue interfaces include complex gradient structures formed by transitioning of biochemical and mechanical properties in micro-scale. This characteristic allows the communication and synchronistic functioning of two adjacent but distinct tissues. It is particularly challenging to restore the function of these complex structures by transplantation of scaffolds exclusively produced by conventional tissue engineering methods. Three-dimensional (3D) bioprinting technology has opened an unprecedented approach for precise and graded patterning of chemical, biological and mechanical cues in a single construct mimicking natural tissue interfaces. This paper reviews and highlights biochemical and biomechanical design for 3D bioprinting of various tissue interfaces, including cartilage-bone, muscle-tendon, tendon/ligament-bone, skin, and neuro-vascular/muscular interfaces. Future directions and translational challenges are also provided at the end of the paper.
Item Type: Article
Uncontrolled Keywords: biofabrication of tissue interfaces; cartilage-bone interface; muscle-tendon interface; neuro-vascular/muscular interface; skin interface; tendon/ligament-bone interface; tissue interface design
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Mine Altunbek
Date Deposited: 06 May 2023 20:44
Last Modified: 06 May 2023 20:44

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