Aptamer-based emerging tools for viral biomarker detection: a focus on SARS-CoV-2

Kulabhusan, Prabir Kumar and Pishva, Parsa and Çapkın, Eda and Tambe, Prajakta and Yüce, Meral (2023) Aptamer-based emerging tools for viral biomarker detection: a focus on SARS-CoV-2. Current Medicinal Chemistry, 30 (8). pp. 910-934. ISSN 0929-8673 (Print) 1875-533X (Online)

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Viral infections can cause fatal illnesses to humans as well as animals. Early detection of viruses is therefore crucial to provide effective treatment to patients. Recent-ly, the Covid-19 pandemic has undoubtedly given an alarming call to develop rapid and sensitive detection platforms. The viral diagnostic tools need to be fast, affordable, and easy to operate with high sensitivity and specificity equivalent or superior to the current-ly used diagnostic methods. The present detection methods include direct detection of viral antigens or measuring the response of antibodies to viral infections. However, the sensitivity and quantification of the virus are still a significant challenge. Detection tools em-ploying synthetic binding molecules like aptamers may provide several advantages over the conventional methods that use antibodies in the assay format. Aptamers are highly stable and tailorable molecules and are therefore ideal for detection and chemical sensing ap-plications. This review article discusses various advances made in aptamer-based viral detection platforms, including electrochemical, optical, and colorimetric methods to detect viruses, specifically SARS-Cov-2. Considering the several advantages, aptamers could be game-changing in designing high-throughput biosensors for viruses and other biomedi-cal applications in the future.
Item Type: Article
Uncontrolled Keywords: Aptamers; biomarkers; biosensors; MERS-CoV; SARS-CoV-2; viruses
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Parsa Pishva
Date Deposited: 25 Apr 2023 14:32
Last Modified: 25 Apr 2023 14:32
URI: https://research.sabanciuniv.edu/id/eprint/45418

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