Fabrication of a dual-drug-loaded smart niosome-g-chitosan polymeric platform for lung cancer treatment

Zarepour, Atefeh and Egil, Abdurrahim Can and Çakmak, Melike Çokol and Esmaeili Rad, Monireh and Cetin, Yüksel and Aydinlik, Şeyma and Özaydın İnce, Gözde and Zarrabi, Ali (2023) Fabrication of a dual-drug-loaded smart niosome-g-chitosan polymeric platform for lung cancer treatment. Polymers, 15 (2). ISSN 2073-4360

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Changes in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system with antibacterial and anticancer capabilities that could be applied for the treatment of lung cancer. It is composed of a niosomal carrier containing curcumin as an anticancer drug and is coated with a chitosan polymeric shell, alongside Rose Bengal (RB) as a photosensitizer with an antibacterial feature. The characterization results confirmed the successful fabrication of lipid-polymeric carriers with a size of nearly 80 nm and encapsulation efficiency of about 97% and 98% for curcumin and RB, respectively. It had the Korsmeyer–Peppas release pattern model with pH and temperature responsivity so that nearly 60% and 35% of RB and curcumin were released at 37 °C and pH 5.5. Moreover, it showed nearly 50% toxicity against lung cancer cells over 72 h and antibacterial activity against Escherichia coli. Accordingly, this nanoformulation could be considered a candidate for the treatment of lung cancer; however, in vivo studies are needed for better confirmation.
Item Type: Article
Uncontrolled Keywords: antibacterial; anticancer; dual responsive nanocarrier; niosome; Rose Bengal
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Materials Science & Eng.
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Gözde Özaydın İnce
Date Deposited: 17 Apr 2023 14:31
Last Modified: 17 Apr 2023 14:31
URI: https://research.sabanciuniv.edu/id/eprint/45385

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