Antioxidant effects of bioactive glasses (BGs) and their significance in tissue engineering strategies

Kargozar, Saeid and Houshmand Rezaghol, Sara and Hosseini, Seyede Atefe and Gorgani, Sara and Kermani, Farzad and Baino, Francesco (2022) Antioxidant effects of bioactive glasses (BGs) and their significance in tissue engineering strategies. Molecules, 27 (19). ISSN 1420-3049

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Elevated levels of oxidative stress are usually observed following injuries, leading to impaired tissue repair due to oxidation-related chronic inflammation. Several attempts have been made to manage this unfavorable situation, and the use of biomaterials with antioxidant activity is showing great promise in tissue engineering and regenerative medicine approaches. Bioactive glasses (BGs) are a versatile group of inorganic substances that exhibit an outstanding regenerative capacity for both hard and soft damaged tissues. The chemical composition of BGs provides a great opportunity for imparting specific biological activities to them. On this point, BGs may easily become antioxidant substances through simple physicochemical modifications. For example, particular antioxidant elements (mostly cerium (Ce)) can be added to the basic composition of the glasses. On the other hand, grafting natural antioxidant substances (e.g., polyphenols) on the BG surface is feasible for making antioxidant substitutes with promising results in vitro. Mesoporous BGs (MBGs) were demonstrated to have unique merits compared with melt-derived BGs since they make it possible to load antioxidants and deliver them to the desired locations. However, there are actually limited in vivo experimental studies on the capability of modified BGs for scavenging free radicals (e.g., reactive oxygen species (ROS)). Therefore, more research is required to determine the actual potential of BGs in decreasing oxidative stress and subsequently improving tissue repair and regeneration. The present work aims to highlight the potential of different types of BGs in modulating oxidative stress and subsequently improving tissue healing.
Item Type: Article
Uncontrolled Keywords: bioactive glasses (BGs); free radicals; oxidative stress; tissue engineering; wound healing
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Sara Houshmand Rezaghol
Date Deposited: 09 Feb 2023 15:50
Last Modified: 09 Feb 2023 15:50

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