Stimuli-responsive liposomal nanoformulations in cancer therapy: pre-clinical & clinical approaches

Ashrafizadeh, Milad and Delfi, Masoud and Zarrabi, Ali and Bigham, Ashkan and Sharifi, Esmaeel and Rabiee, Navid and Paiva-Santos, Ana Cláudia and Kumar, Alan Prem and Tan, Shing Cheng and Hushmandi, Kiavash and Ren, Jun and Zare, Ehsan Nazarzadeh and Makvandi, Pooyan (2022) Stimuli-responsive liposomal nanoformulations in cancer therapy: pre-clinical & clinical approaches. Journal of Controlled Release, 351 . pp. 50-80. ISSN 0168-3659 (Print) 1873-4995 (Online)

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Abstract

The site-specific delivery of antitumor agents is of importance for providing effective cancer suppression. Poor bioavailability of anticancer compounds and the presence of biological barriers prevent their accumulation in tumor sites. These obstacles can be overcome using liposomal nanostructures. The challenges in cancer chemotherapy and stimuli-responsive nanocarriers are first described in the current review. Then, stimuli-responsive liposomes including pH-, redox-, enzyme-, light-, thermo- and magneto-sensitive nanoparticles are discussed and their potential for delivery of anticancer drugs is emphasized. The pH- or redox-sensitive liposomes are based on internal stimulus and release drug in response to a mildly acidic pH and GSH, respectively. The pH-sensitive liposomes can mediate endosomal escape via proton sponge. The multifunctional liposomes responsive to both redox and pH have more capacity in drug release at tumor site compared to pH- or redox-sensitive alone. The magnetic field and NIR irradiation can be exploited for external stimulation of liposomes. The light-responsive liposomes release drugs when they are exposed to irradiation; thermosensitive-liposomes release drugs at a temperature of >40 °C when there is hyperthermia; magneto-responsive liposomes release drugs in presence of magnetic field. These smart nanoliposomes also mediate co-delivery of drugs and genes in synergistic cancer therapy. Due to lack of long-term toxicity of liposomes, they can be utilized in near future for treatment of cancer patients.
Item Type: Article
Uncontrolled Keywords: Advanced nanostructures; Cancer therapy; Drug resistance; Liposomes; Targeted delivery
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Milad Ashrafizadeh
Date Deposited: 23 Mar 2023 16:17
Last Modified: 23 Mar 2023 16:17
URI: https://research.sabanciuniv.edu/id/eprint/45099

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