Monoclonal antibodies for diagnostic and therapeutic systems to combat microbial infections

Pishva, Parsa and Kayalan, Cemre Irmak and Sert, Fatma and Yüce, Meral (2022) Monoclonal antibodies for diagnostic and therapeutic systems to combat microbial infections. In: Saravanan, Muthupandian and Barabadi, Hamed and Mostafavi, Ebrahim and Webster, Thomas, (eds.) Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance. Elsevier, -, pp. 627-660. ISBN 9780323998109 (Print) 9780323907927 (Online)

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Diagnosis and effective therapy of microbial infections are often complicated processes. Antibodies can be used for rapid, specific diagnosis and therapy of those infections because of target selectivity and specificity. Monoclonal antibodies show higher target specificity compared to polyclonal antibodies. Single epitopes specificity of monoclonal antibodies makes them the leading therapeutic and diagnostic tool against microbial infections by lowering the potential of off-target reactions and misleading diagnosis. Employing monoclonal antibodies to diagnose and treat microbial infections has been attracting significant attention despite some economic obstacles. This chapter focuses on the potential diagnostic and therapeutic use of monoclonal antibodies to combat different microbial infections, including bacterial infections, viral infections, and some other infections in vivo and in vitro. The recent advances made in monoclonal antibody development against various microbial diseases for diagnostic and therapeutic purposes are discussed. Finally, some key challenges in designing, manufacturing, and developing monoclonal antibodies for diagnostic and therapeutic systems and their limitations and future trends are explained.
Item Type: Book Section / Chapter
Uncontrolled Keywords: Diagnostic; Microbial infections; Monoclonal antibodies; Therapy
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Meral Yüce
Date Deposited: 23 Mar 2023 15:19
Last Modified: 23 Mar 2023 15:19

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