Chitosan-based nanoscale systems for doxorubicin delivery: exploring biomedical application in cancer therapy

Ashrafizadeh, Milad and Hushmandi, Kiavash and Mirzaei, Sepideh and Bokaie, Saied and Bigham, Ashkan and Makvandi, Pooyan and Rabiee, Navid and Thakur, Vijay Kumar and Kumar, Alan Prem and Sharifi, Esmaeel and Varma, Rajender S. and Aref, Amir Reza and Wojnilowicz, Marcin and Zarrabi, Ali and Karimi-Maleh, Hassan and Voelcker, Nicolas H. and Mostafavi, Ebrahim and Orive, Gorka (2023) Chitosan-based nanoscale systems for doxorubicin delivery: exploring biomedical application in cancer therapy. Bioengineering and Translational Medicine, 8 (1). ISSN 2380-6761

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Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS-based nanoparticles (CS-NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS-NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P-glycoprotein (P-gp) to reverse drug resistance. These nanoarchitectures can provide co-delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co-loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid-, carbon-, polymeric- and metal-based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS-NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS-NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH-sensitive release of DOX can occur. Furthermore, redox- and light-responsive CS-NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS-NPs, we expect to soon see significant progress towards clinical translation.
Item Type: Article
Uncontrolled Keywords: chitosan; drug resistance; gene therapy; stimuli-responsive nanocarriers; synergistic therapy
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Milad Ashrafizadeh
Date Deposited: 23 Mar 2023 12:18
Last Modified: 23 Mar 2023 12:18

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