A hybrid spiral microfluidic platform for separation of circulating tumor cells

Altay, Rana and Koşar, Ali and Yapıcı, Murat Kaya (2021) A hybrid spiral microfluidic platform for separation of circulating tumor cells. In: 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2021), Palm Springs, Virtual, USA

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In this study, a hybrid microfluidic platform consisting of passive and active components was simulated to obtain a precise and enhanced separation of circulating tumor cells (CTCs). In the first stage of the system, the focusing of particles of varying sizes representing different cell lines was achieved by a two-loop spiral microchannel structure which was followed by exposing the standing surface acoustic waves (SSAW) to the particles. The merger of inertial focusing with SSAW facilitated the trapping of the particles along nodal lines leading to the five outlets and the proposed two-step approach was shown to increase the sensitivity of separation as indicated by the excellent localization of the 20 μm particles along the nodal lines whereas the 6 μm and 9 μm showed clear dispersion and mixing.
Item Type: Papers in Conference Proceedings
Uncontrolled Keywords: Acoustofluidics; Cell Separation; Circulating Tumor Cells (CTCs); Inertial Microfluidics
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Koşar
Date Deposited: 21 Sep 2022 15:01
Last Modified: 21 Sep 2022 15:01
URI: https://research.sabanciuniv.edu/id/eprint/44496

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