Inorganic nanomaterials for improved angiogenesis

Houshmand Rezagholizadeh, Sara and Kim, Hae-Won and Kargozar, Saeid and Darroudi, Majid (2022) Inorganic nanomaterials for improved angiogenesis. In: Kargozar, Saeid and Mozafari, Masoud, (eds.) Biomaterials for Vasculogenesis and Angiogenesis. Woodhead Publishing Series in Biomaterials. Elsevier, US, pp. 335-359. ISBN 978-0-12-821867-9

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Angiogenesis, the process of new blood vessel formation, is orchestrated by a series of chemical signals in the human body, leading to the growth, migration, and differentiation of endothelial cells (ECs) inside the wall blood vessels. During the last decade, nanomaterials' role in advancing or prohibiting angiogenesis has been well-studied; inorganic nanoparticles are among the most promising tools in regulating neovascularization. Physicochemical characteristics of nanosized materials determine their ability to stimulate or suppress the angiogenesis process. Apart from the nature of chemical elements, the particle size, shape, surface charge, and administrated concentrations are mentioned as decisive parameters in governing the fate of cellular and molecular mechanisms involved in the angiogenesis process. Nowadays, inorganic nanoscale materials are being utilized in imaging angiogenesis in both healthy and pathological conditions. Still, there are serious concerns about the potential toxicity of inorganic nanoparticles for the body, limiting their extensive usage in managing various diseases and disorders in which imbalance of angiogenesis is observed.
Item Type: Book Section / Chapter
Uncontrolled Keywords: Nanomaterials; Inorganic nanoparticles; Angiogenesis; Tissue Engineering; Cancer theranostics
Subjects: Q Science > QD Chemistry > QD071-142 Analytical chemistry
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Sara Houshmand Rezaghol
Date Deposited: 09 Sep 2022 15:27
Last Modified: 23 Mar 2023 15:38

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