Dendrimers as nanoscale vectors: unlocking the bars of cancer therapy

Dey, Asmita Deka and Bigham, Ashkan and Esmaeili, Yasaman and Ashrafizadeh, Milad and Moghaddam, Farnaz Dabbagh and Tan, Shing Cheng and Yousefiasl, Satar and Sharma, Saurav and Maleki, Aziz and Rabiee, Navid and Kumar, Alan Prem and Thakur, Vijay Kumar and Orive, Gorka and Sharifi, Esmaeel and Kumar, Arun and Makvandi, Pooyan (2022) Dendrimers as nanoscale vectors: unlocking the bars of cancer therapy. Seminars in Cancer Biology . ISSN 1044-579X (Print) 1096-3650 (Online) Published Online First https://dx.doi.org/10.1016/j.semcancer.2022.06.003

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Abstract

Chemotherapy is the first choice in the treatment of cancer and is always preferred to other approaches such as radiation and surgery, but it has never met the need of patients for a safe and effective drug. Therefore, new advances in cancer treatment are now needed to reduce the side effects and burdens associated with chemotherapy for cancer patients. Targeted treatment using nanotechnology are now being actively explored as they could effectively deliver therapeutic agents to tumor cells without affecting normal cells. Dendrimers are promising nanocarriers with distinct physiochemical properties that have received considerable attention in cancer therapy studies, which is partly due to the numerous functional groups on their surface. In this review, we discuss the progress of different types of dendrimers as delivery systems in cancer therapy, focusing on the challenges, opportunities, and functionalities of the polymeric molecules. The paper also reviews the various role of dendrimers in their entry into cells via endocytosis, as well as the molecular and inflammatory pathways in cancer. In addition, various dendrimers-based drug delivery (e.g., pH-responsive, enzyme-responsive, redox-responsive, thermo-responsive, etc.) and lipid-, amino acid-, polymer- and nanoparticle-based modifications for gene delivery, as well as co-delivery of drugs and genes in cancer therapy with dendrimers, are presented. Finally, biosafety concerns and issues hindering the transition of dendrimers from research to the clinic are discussed to shed light on their clinical applications.
Item Type: Article
Uncontrolled Keywords: Cancer; Chemotherapy; Dendrimers; Drug and gene delivery; Targeted therapy
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 21 Aug 2022 12:52
Last Modified: 21 Aug 2022 12:52
URI: https://research.sabanciuniv.edu/id/eprint/44249

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