Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Paskeh, Mahshid Deldar Abad and Entezari, Maliheh and Mirzaei, Sepideh and Zabolian, Amirhossein and Saleki, Hossein and Naghdi, Mohamad Javad and Sabet, Sina and Khoshbakht, Mohammad Amin and Hashemi, Mehrdad and Hushmandi, Kiavash and Sethi, Gautam and Zarrabi, Ali and Kumar, Alan Prem and Tan, Shing Cheng and Papadakis, Marios and Alexiou, Athanasios and Islam, Md Asiful and Mostafavi, Ebrahim and Ashrafizadeh, Milad (2022) Emerging role of exosomes in cancer progression and tumor microenvironment remodeling. Journal of Hematology and Oncology, 15 (1). ISSN 1756-8722

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Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment.
Item Type: Article
Uncontrolled Keywords: Biomarker; Cancer; Exosome; Immunotherapy; Non-coding RNA; Prognosis
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Milad Ashrafizadeh
Date Deposited: 21 Aug 2022 13:28
Last Modified: 21 Aug 2022 13:28
URI: https://research.sabanciuniv.edu/id/eprint/44242

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