Lysostaphin-functionalized waterborne polyurethane/polydopamine coatings effective against S. aureus biofilms

Alkan Taş, Buket and Berksun, Ekin and Taş, Cüneyt Erdinç and Ünal, Serkan and Ünal, Hayriye (2022) Lysostaphin-functionalized waterborne polyurethane/polydopamine coatings effective against S. aureus biofilms. ACS Applied Polymer Materials, 4 (6). pp. 4298-4305. ISSN 2637-6105

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Hybrid waterborne polyurethane/polydopamine (WPU/PDA) matrix, showing the adhesive properties of PDA in its entirety, was utilized for the immobilization of lysostaphin (Lys), an important anti-staphylococcal agent, to obtain highly effective antibacterial and antibiofilm surface coatings. WPU/PDA matrix prepared by the encapsulation of WPU particles with PDA in aqueous dispersion was applied as coatings on substrates, and the facile incubation of the WPU/PDA-coated surfaces with Lys in aqueous solution resulted in WPU/PDA/Lys coatings that contained immobilized Lys on the surface. WPU/PDA/Lys coatings showed strong anti-Staphylococcus aureus activity with a 4 log reduction in the number of cells. Furthermore, WPU/PDA/Lys coatings were demonstrated to be durable without any enzyme leakage, and their antibacterial activity was preserved for at least 30 days and over multiple exposures to bacteria. WPU/PDA/Lys coatings presented significant antibiofilm activity against S. aureus with a 3.5 log reduction in the number of surface-attached bacteria. WPU/PDA/Lys coatings that are easy-to-apply to almost any surface, non-toxic, and environmentally friendly provide promising antibacterial and antibiofilm surfaces that are effective against S. aureus.
Item Type: Article
Uncontrolled Keywords: antibacterial coating; antibiofilm coating; lysostaphin; polydopamine; waterborne polyurethane (WPU)
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Integrated Manufacturing Technologies Research and Application Center
Depositing User: Serkan Ünal
Date Deposited: 21 Aug 2022 21:52
Last Modified: 21 Aug 2022 21:52

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