Three-dimensional-bioprinted liver chips and challenges

Dabbagh, Sajjad Rahmani and Ozdalgic, Berin and Mustafaoğlu, Nur and Tasoglu, Savas (2022) Three-dimensional-bioprinted liver chips and challenges. Applied Sciences (Switzerland), 12 (10). ISSN 2076-3417

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Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries. Integrating 3D bioprinting with microfluidic chips to fabricate organ-on-chip platforms for 3D liver cell cultures with continuous perfusion can offer a more physiologically relevant liver-mimetic platform for screening drugs and studying liver function. The development of organ-on-chip platforms may ultimately contribute to personalized medicine as well as body-on-chip technology that can test drug responses and organ–organ interactions on a single or linked chip model.
Item Type: Article
Uncontrolled Keywords: bioprinting; liver; organ-on-a-chip; tissue-on-a-chip
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Nur Mustafaoğlu
Date Deposited: 22 Aug 2022 11:39
Last Modified: 22 Aug 2022 11:39

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