In vitro human cancer models for biomedical applications

Choi, Jane Ru and Kozalak, Gül and Di Bari, Ighli and Babar, Quratulain and Niknam, Zahra and Rasmi, Yousef and Yong, Kar Wey (2022) In vitro human cancer models for biomedical applications. Cancers, 14 (9). ISSN 2072-6694

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Cancer is one of the leading causes of death worldwide, and its incidence is steadily increasing. Although years of research have been conducted on cancer treatment, clinical treatment options for cancers are still limited. Animal cancer models have been widely used for studies of cancer therapeutics, but these models have been associated with many concerns, including inaccuracy in the representation of human cancers, high cost and ethical issues. Therefore, in vitro human cancer models are being developed quickly to fulfill the increasing demand for more relevant models in order to get a better knowledge of human cancers and to find novel treatments. This review summarizes the development of in vitro human cancer models for biomedical applications. We first review the latest development in the field by detailing various types of in vitro human cancer models, including transwell-based models, tumor spheroids, microfluidic tumor-microvascular systems and scaffold-based models. The advantages and limitations of each model, as well as their biomedical applications, are summarized, including therapeutic development, assessment of tumor cell migration, metastasis and invasion and discovery of key cancer markers. Finally, the existing challenges and future perspectives are briefly discussed.
Item Type: Article
Uncontrolled Keywords: biomedical applications; cancer markers; human cancers; in vitro model; therapeutic development; tumor biology
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Gül Kozalak
Date Deposited: 22 Aug 2022 15:29
Last Modified: 05 Oct 2023 15:39

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