Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing

Abadehie, Fatemeh Saniee and Dehkordi, Ali Hasanpour and Zafari, Mahdi and Bagheri, Mitra and Yousefiasl, Satar and Pourmotabed, Samiramis and Mahmoodnia, Leila and Validi, Majid and Ashrafizadeh, Milad and Zare, Ehsan Nazarzadeh and Rabiee, Navid and Makvandi, Pooyan and Sharifi, Esmaeel (2022) Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing. Engineered Regeneration, 2 . pp. 219-226. ISSN 2666-1381

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Abstract

Biodegradable and absorptive wound dresses with antibacterial activity are in demand to accelerate wound healing along with eliminating bacterial infection. Plant-derived naphthoquinones compounds such as lawsone have shown sustained antibacterial functions to avoid development of bacterial resistance by reducing pH or attaching to bacterial proteins. Here the nanofibrous mats based on chitosan/polyethylene oxide (PEO) fibers containing various concentrations of lawsone (0, 1, 3, 7, 10% wt.) were fabricated by electrospinning for potential applications as wound dressing materials. The results exhibited that the chitosan/PEO/Lawsone nanofibers possess antibacterial activity toward Gram-negative and -positive bacteria. Surprisingly, the addition of lawsone in the proper amount into chitosan/PEO nanofibers not only introduced an antithetical property but also reduced the platform's cytotoxicity, promoting cell viability of normal human fibroblast cells. Accordingly, the achieved data suggest the potential application of biocompatible nanofibrous mats as an antibacterial wound dressing material.
Item Type: Article
Uncontrolled Keywords: Antibacterial wound dressing; Chitosan; Lawsone; Nanofibrous mat
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 22 Aug 2022 16:13
Last Modified: 22 Aug 2022 16:13
URI: https://research.sabanciuniv.edu/id/eprint/44148

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