Characterization of biological molecule–loaded nanostructures using circular dichroism and fourier transform infrared spectroscopy

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Parlar, Ayhan and Kulabhusan, Prabir Kumar and Kurt, Hasan and Gürel, Büşra and Torabfam, Milad and Özata, Başak and Yüce, Meral (2021) Characterization of biological molecule–loaded nanostructures using circular dichroism and fourier transform infrared spectroscopy. In: Çapan, Yılmaz and Sahin, Adem and Tonbul, Hayrettin, (eds.) Drug Delivery with Targeted Nanoparticles: In Vitro and in Vivo Evaluation Methods. Taylor and Francis, New York, pp. 131-146. ISBN 9781003164739 (Ebook)

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Abstract

Drug-loaded nanoparticles have many advantages in drug administration, which is an essential step for the impact of the drugs and their mechanism of action. Circular dichroism (CD) is a spectroscopy technique that measures the absorbance difference between right-circularly polarized light and left-circularly polarized light. Of several analytical techniques available, Fourier transform infrared spectroscopy is a powerful and widely employed technique explicitly for identifying chemical species. The peaks in the IR spectrum of a sample represent the molecular vibrations of the molecules present in the sample, signifying the various chemical bonds and functional groups. Various types of nanoparticles are being utilized for drug delivery applications because of their advantages such as controlled drug release, protection of the therapeutic payload, improved bioavailability, and targeted delivery. The discovery of novel nanoparticles and their application to the diagnosis and treatment of diseases have received considerable attention during the past decades.
Item Type: Book Section / Chapter
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ayhan Parlar
Date Deposited: 22 Aug 2022 21:00
Last Modified: 22 Aug 2022 21:00
URI: https://research.sabanciuniv.edu/id/eprint/44125

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