Non-coding RNAs and macrophage interaction in tumor progression

Entezari, Maliheh and Sadrkhanloo, Mehrdokht and Rashidi, Mohsen and Asnaf, Sholeh Etehad and Taheriazam, Afshin and Hashemi, Mehrdad and Ashrafizadeh, Milad and Zarrabi, Ali and Rabiee, Navid and Hushmandi, Kiavash and Mirzaei, Sepideh and Sethi, Gautam (2022) Non-coding RNAs and macrophage interaction in tumor progression. Critical Reviews in Oncology/Hematology, 173 . ISSN 1040-8428 (Print) 1879-0461 (Online)

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The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. The miRNAs can dually induce/suppress M2 polarization of macrophages and by affecting various molecular pathways, they modulate tumor progression and therapy response. The lncRNAs can affect miRNAs via sponging and other molecular pathways to modulate macrophage polarization. A few experiments have also examined role of circRNAs in targeting signaling networks and affecting macrophages. The therapeutic targeting of these ncRNAs can mediate TME remodeling and affect macrophage polarization. Furthermore, exosomal ncRNAs derived from tumor cells or macrophages can modulate polarization and TME remodeling. Suppressing biogenesis and secretion of exosomes can inhibit ncRNA-mediated M2 polarization of macrophages and prevent tumor progression. The ncRNAs, especially exosomal ncRNAs can be considered as non-invasive biomarkers for tumor diagnosis.
Item Type: Article
Uncontrolled Keywords: Cancer therapy; CircRNAs; Drug resistance; Exosomes; Long non-coding RNAs; MiRNAs
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Milad Ashrafizadeh
Date Deposited: 22 Aug 2022 22:15
Last Modified: 22 Aug 2022 22:15

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