Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations

Warning The system is temporarily closed to updates for reporting purpose.

Tutar, Rumeysa and Yüce-Erarslan, Elif and İzbudak, Burçin and Bal-Öztürk, Ayça (2022) Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations. Journal of Materials Chemistry B, 10 (15). pp. 2912-2925. ISSN 2050-750X (Print) 2050-7518 (Online)

Full text not available from this repository. (Request a copy)

Abstract

Corneal defects are associated with corneal tissue engineering in terms of vision loss. The treatment of corneal defects is an important clinical challenge due to a uniform corneal thickness and the apparent lack of regenerative ability. In this work, we synthesized a biocompatible and photocrosslinkable ocular tissue adhesive composite hydrogel prepared by using methacrylated gelatin (GelMA), which is called the most favorable derivative of gelatin used as a tissue adhesive, silk fibroin (SF), and GelMA/SF (GS) with high adhesion behaviours for use in corneal injuries. The adhesion behaviours of the materials prepared in the presence of silk fibroin were improved. Importantly, the effect of different UV curing times on the adhesion properties of the prepared materials was also investigated. The prepared GS tissue adhesives showed high physiological adhesion. GS can be modulated to increase its adhesive strength up to 3 times compared to G. GS was also found to be biocompatible and have a high healing potential. In addition, the obtained transmission value of GS is also close to that of the human cornea. GS supported cellular adhesion and proliferation. The burst pressure strength for fresh cornea of the GS-60s sealants (144.5 ± 13 kPa) was determined to be higher than that of the G-60s sealants (52.6 ± 33.5 kPa).
Item Type: Article
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: IC-Cataloging
Date Deposited: 23 Aug 2022 11:08
Last Modified: 23 Aug 2022 11:08
URI: https://research.sabanciuniv.edu/id/eprint/44108

Actions (login required)

View Item
View Item