Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance

Ashrafizadeh, Milad and Saebfar, Hamidreza and Gholami, Mohammad Hossein and Hushmandi, Kiavash and Zabolian, Amirhossein and Bikarannejad, Pooria and Hashemi, Mehrdad and Daneshi, Salman and Mirzaei, Sepideh and Sharifi, Esmaeel and Kumar, Alan Prem and Khan, Haroon and Heydari Sheikh Hossein, Hamid and Vosough, Massoud and Rabiee, Navid and Kumar Thakur, Vijay and Makvandi, Pooyan and Mishra, Yogendra Kumar and Tay, Franklin R. and Wang, Yuzhuo and Zarrabi, Ali and Orive, Gorka and Mostafavi, Ebrahim (2022) Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance. Expert Opinion on Drug Delivery, 19 (4). pp. 355-382. ISSN 1742-5247 (Print) 1744-7593 (Online)

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Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting its cytotoxicity in cancer. Areas covered: The favorable characteristics of GO nanocomposites, preparation method, and application in cancer therapy are described. Then, DOX resistance in cancer, GO-mediated photothermal therapy, and DOX delivery for cancer suppression are described. Preparation of stimuli-responsive GO nanocomposites, surface functionalization, hybrid nanoparticles, and theranostic applications are emphasized in DOX chemotherapy. Expert opinion: GO nanoparticle-based photothermal therapy maximizes the anti-cancer activity of DOX against cancer cells. Besides DOX delivery, GO nanomaterials are capable of loading anti-cancer agents and genetic tools to minimize drug resistance and enhance the cytolytic impact of DOX in cancer eradication. To enhance DOX accumulation, stimuli-responsive (redox-, light-, enzyme- and pH-sensitive) GO nanoparticles have been developed for DOX delivery. Development of targeted delivery of DOX-loaded GO nanomaterials against cancer cells may be achieved by surface modification of polymers such as polyethylene glycol, hyaluronic acid, and chitosan. DOX-loaded GO nanoparticles have demonstrated theranostic potential. Hybridization of GO with other nanocarriers such as silica and gold nanoparticles further broadens their potential anti-cancer therapy applications.
Item Type: Article
Uncontrolled Keywords: Anti-cancer chemotherapy; carbon nanomaterials; doxorubicin; drug resistance; graphene oxide; stimuli-responsive
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Milad Ashrafizadeh
Date Deposited: 23 Aug 2022 14:32
Last Modified: 23 Aug 2022 14:32

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