Pharmaceutical applications of a nanospectroscopic technique: surface-enhanced Raman spectroscopy

Yılmaz, Hülya and Yılmaz, Deniz and Taskin, Irem Culha and Çulha, Mustafa (2022) Pharmaceutical applications of a nanospectroscopic technique: surface-enhanced Raman spectroscopy. Advanced Drug Delivery Reviews, 184 . ISSN 0169-409X (Print) 1872-8294 (Online)

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Surface-enhanced Raman spectroscopy (SERS) is a very sensitive technique offering unique opportunities for detection and identification of molecules and molecular structures at extremely low concentrations even in complex sample matrixes. Since a nanostructured noble metal surface is required for the enhancement of Raman scattering, the acquired spectral information naturally originates from nanometer size domains making it a nanospectroscopic technique by breaking the diffraction limit of light. In this review, first Raman spectroscopy, its comparison to other related techniques, its modes and instrumentation are briefly introduced. Then, the SERS mechanism, substrates and the parameters influencing a SERS experiment are discussed. Finally, its applications in pharmaceuticals including drug discovery, drug metabolism, multifunctional chemo-photothermal-therapy-delivery-release-imaging, drug stability and drug/metabolite detection in complex biological samples are summarized and elaborated.
Item Type: Article
Uncontrolled Keywords: Biomedical Imaging; Detection; Drug Delivery; Drug Discover; Drug Stability; Nanospectroscopy; Pharmaceuticals; Surface-enhanced Raman Spectroscopy (SERS)
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Hülya Yılmaz
Date Deposited: 23 Aug 2022 22:19
Last Modified: 23 Aug 2022 22:19

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