Bone bricks: the effect of architecture and material composition on the mechanical and biological performance of bone scaffolds

Warning The system is temporarily closed to updates for reporting purpose.

Daskalakis, Evangelos and Huang, Boyang and Vyas, Cian and Acar, Anıl Ahmet and Liu, Fengyuan and Fallah, Ali and Cooper, Glen and Weightman, Andrew and Blunn, Gordon and Koç, Bahattin and Bartolo, Paulo (2022) Bone bricks: the effect of architecture and material composition on the mechanical and biological performance of bone scaffolds. ACS Omega, 7 (9). pp. 7515-7530. ISSN 2470-1343

Full text not available from this repository. (Request a copy)

Abstract

Large bone loss injuries require high-performance scaffolds with an architecture and material composition resembling native bone. However, most bone scaffold studies focus on three-dimensional (3D) structures with simple rectangular or circular geometries and uniform pores, not able to recapitulate the geometric characteristics of the native tissue. This paper addresses this limitation by proposing novel anatomically designed scaffolds (bone bricks) with nonuniform pore dimensions (pore size gradients) designed based on new lay-dawn pattern strategies. The gradient design allows one to tailor the properties of the bricks and together with the incorporation of ceramic materials allows one to obtain structures with high mechanical properties (higher than reported in the literature for the same material composition) and improved biological characteristics.
Item Type: Article
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Integrated Manufacturing Technologies Research and Application Center
Depositing User: Bahattin Koç
Date Deposited: 24 Aug 2022 12:14
Last Modified: 24 Aug 2022 12:14
URI: https://research.sabanciuniv.edu/id/eprint/44055

Actions (login required)

View Item
View Item