Folic acid-adorned curcumin-loaded iron oxide nanoparticles for cervical cancer

Ramezani Farani, Marzieh and Azarian, Maryam and Heydari Sheikh Hossein, Hamid and Abdolvahabi, Zohreh and Mohammadi Abgarmi, Zahra and Moradi, Arash and Mousavi, Seyyedeh Maedeh and Ashrafizadeh, Milad and Makvandi, Pooyan and Saeb, Mohammad Reza and Rabiee, Navid (2022) Folic acid-adorned curcumin-loaded iron oxide nanoparticles for cervical cancer. ACS Applied Bio Materials, 5 (3). pp. 1305-1318. ISSN 2576-6422

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Cancer is a deadly disease that has long plagued humans and has become more prevalent in recent years. The common treatment modalities for this disease have always faced many problems and complications, and this has led to the discovery of strategies for cancer diagnosis and treatment. The use of magnetic nanoparticles in the past two decades has had a significant impact on this. One of the objectives of the present study is to introduce the special properties of these nanoparticles and how they are structured to load and transport drugs to tumors. In this study, iron oxide (Fe3O4) nanoparticles with 6 nm sizes were coated with hyperbranched polyglycerol (HPG) and folic acid (FA). The functionalized nanoparticles (10-20 nm) were less likely to aggregate compared to non-functionalized nanoparticles. HPG@Fe3O4and FA@HPG@Fe3O4nanoparticles were compared in drug loading procedures with curcumin. HPG@Fe3O4and FA@HPG@Fe3O4nanoparticles' maximal drug-loading capacities were determined to be 82 and 88%, respectively. HeLa cells and mouse L929 fibroblasts treated with nanoparticles took up more FA@HPG@Fe3O4nanoparticles than HPG@Fe3O4nanoparticles. The FA@HPG@Fe3O4nanoparticles produced in the current investigation have potential as anticancer drug delivery systems. For the purpose of diagnosis, incubation of HeLa cells with nanoparticles decreased MRI signal enhancement's percentage and the largest alteration was observed after incubation with FA@HPG@Fe3O4 nanoparticles.
Item Type: Article
Uncontrolled Keywords: cervical cancer therapy; curcumin; iron oxide nanoparticles; MRI; polyglycerol; targeted delivery
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 24 Aug 2022 15:12
Last Modified: 24 Aug 2022 15:12

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