Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches

Ashrafizadeh, Milad and Ahmadi, Zahra and Yaribeygi, Habib and Sathyapalan, Thozhukat and Sahebkar, Amirhossein (2022) Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches. Mini-Reviews in Medicinal Chemistry, 22 (2). pp. 312-321. ISSN 1389-5575 (Print) 1875-5607 (Online)

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Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favourable biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, anti-diabetes, hepatoprotective, and neuroprotective activities. Nevertheless, the exact molecular mechanisms of these protective effects of AST are unclear yet. The Nrf2 signaling pathway is one of the critical candidate signaling pathways that may be involved in these beneficial effects of AST. This signaling pathway is responsible for maintaining the redox balance in the physiological state. Upon nuclear translocation, Nrf2 signaling activates antioxidant enzymes to reduce oxidative stress and protect cells against damage. In the current study, we have reviewed the effects of AST on the Nrf2 signaling pathway, which could potentially be developed as a novel therapeutic approach for the management of various diseases.
Item Type: Article
Uncontrolled Keywords: Astaxanthin; Cardioprotective; Diabetes mellitus; Neuroprotective; Nrf2 signaling pathway; Oxidative stress; Renoprotective
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 25 Aug 2022 12:53
Last Modified: 25 Aug 2022 12:53

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