The effects of ginsenosides on the Nrf2 signaling pathway

Ashrafizadeh, Milad and Ahmadi, Zahra and Yaribeygi, Habib and Sathyapalan, Thozhukat and Jamialahmadi, Tannaz and Sahebkar, Amirhossein (2021) The effects of ginsenosides on the Nrf2 signaling pathway. In: Sahebkar, Amirhossein and Sathyapalan, Thozhukat, (eds.) Natural Products and Human Diseases: Pharmacology, Molecular Targets, and Therapeutic Benefits. Advances in Experimental Medicine and Biology; 1328. Springer Cham, Switzerland, pp. 307-322. ISBN 978-3-030-73233-2 (Print) 978-3-030-73234-9 (Online)

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Nuclear factor erythroid-2 related factor 2 (Nrf2) is a major signaling pathway for the maintenance of homeostasis and redox balance. This pathway also plays a significant role in proteostasis, xenobiotic/drug metabolism, apoptosis, and lipid and carbohydrate metabolism. Conversely, the Nrf2 signaling pathway is impaired in several pathological conditions including cancer. Although various drugs have been developed to target the Nrf2 pathway, plant-derived chemicals than can potentially impact this pathway and are particularly attractive due to their minimal side effects. Ginsenosides are active components of ginseng and have been shown to exert pharmacological effects including antioxidant, anti-inflammatory, antitumor, antidiabetes, neuroprotective, and hepatoprotective activities. In this article, we have reviewed the effects of ginsenosides on Nrf2 signaling pathway.
Item Type: Book Section / Chapter
Uncontrolled Keywords: Ginseng; Ginsenosides; Herbal medicine; Nrf2 signaling pathway; Protective effects
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 26 Aug 2022 11:53
Last Modified: 26 Aug 2022 11:53

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