Pre-clinical and clinical applications of small interfering rnas (Sirna) and co-delivery systems for pancreatic cancer therapy

Mirzaei, Sepideh and Gholami, Mohammad Hossein and Ang, Hui Li and Hashemi, Farid and Zarrabi, Ali and Zabolian, Amirhossein and Hushmandi, Kiavash and Delfi, Masoud and Khan, Haroon and Ashrafizadeh, Milad and Sethi, Gautam and Kumar, Alan Prem (2021) Pre-clinical and clinical applications of small interfering rnas (Sirna) and co-delivery systems for pancreatic cancer therapy. Cells, 10 (12). ISSN 2073-4409

Full text not available from this repository. (Request a copy)


Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for development of PC. Small interfering RNA (siRNA) is a powerful genetic tool that can bind to its target and reduces expression level of a specific gene. The various critical genes involved in PC progression can be effectively targeted using diverse siRNAs. Moreover, siRNAs can enhance efficacy of chemotherapy and radiotherapy in inhibiting PC progression. However, siRNAs suffer from different off target effects and their degradation by enzymes in serum can diminish their potential in gene silencing. Loading siRNAs on nanoparticles can effectively protect them against degradation and can inhibit off target actions by facilitating targeted delivery. This leads to enhanced efficacy of siRNAs in PC therapy. Moreover, different kinds of nanoparticles such as polymeric nanoparticles, lipid nanoparticles and metal nanostructures have been applied for optimal delivery of siRNAs that are discussed in this article. This review also reveals that how naked siRNAs and their delivery systems can be exploited in treatment of PC and as siRNAs are currently being applied in clinical trials, significant progress can be made by translating the current findings into the clinical settings.
Item Type: Article
Uncontrolled Keywords: Co-delivery; Drug resistance; Nanoparticles; Pancreatic cancer; Small interfering RNA (siRNA)
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 27 Aug 2022 13:28
Last Modified: 27 Aug 2022 13:28

Actions (login required)

View Item
View Item