Hyaluronic acid (HA)-Gd(III) and HA-Fe(III) microgels as MRI contrast enhancing agents

Sahiner, Nurettin and Umut, Evrim and Suner, Selin S. and Sahiner, Mehtap and Çulha, Mustafa and Ayyala, Ramesh S. (2022) Hyaluronic acid (HA)-Gd(III) and HA-Fe(III) microgels as MRI contrast enhancing agents. Carbohydrate Polymers, 277 . ISSN 0144-8617 (Print) 1879-1344 (Online)

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Hyaluronic acid (HA) was crosslinked with Gd(III) and Fe(III) ions rendering physically crosslinked HA-metal(III) microgels as magnetic resonance imaging (MRI) enhancing contrast agents. These HA-Gd(III) and HA-Fe(III) microgels are injectable with size range, 50–5000 nm in water. The same isoelectric point, pH 1.2 ± 0.1, was measured for both microgels. HA-Gd(III) and HA-Fe(III) microgels are hemo-compatible biomaterials and can be safely used in intravascular applications up to 1000 μg/mL concentration. Furthermore, no significant toxicity was attained as 95 ± 8 and 81 ± 2% cell viability on L929 fibroblast cells at 100 μg/mL of HA-Gd(III) and HA-Fe(III) microgels were measured. Moreover, HA-Gd(III) microgels were found to afford significant contrast improvement capability in MRI with proton relaxivity, r1 = 2.11 mM−1 s−1, comparable with the values reported for Gd(III) labeled functionalized HA gel systems and commercial Gd based contrast agents.
Item Type: Article
Uncontrolled Keywords: Blood compatible; Fe(II) chelating; HA-Fe(III) microgel; HA-Gd(III) microgel; Hyaluronic acid (HA); Magnetic resonance imaging (MRI)
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Mustafa Çulha
Date Deposited: 27 Aug 2022 13:35
Last Modified: 27 Aug 2022 13:35
URI: https://research.sabanciuniv.edu/id/eprint/43877

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