Gene regulation by antisense transcription: a focus on neurological and cancer diseases

Najafi, Sajad and Tan, Shing Cheng and Raee, Pourya and Rahmati, Yazdan and Asemani, Yahya and Lee, E. Hui Clarissa and Hushmandi, Kiavash and Zarrabi, Ali and Aref, Amir Reza and Ashrafizadeh, Milad and Kumar, Alan Prem and Ertas, Yavuz Nuri and Ghani, Sepideh and Aghamiri, Shahin (2022) Gene regulation by antisense transcription: a focus on neurological and cancer diseases. Biomedicine and Pharmacotherapy, 145 . ISSN 0753-3322 (Print) 1950-6007 (Online)

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Advances in high-throughput sequencing over the past decades have led to the identification of thousands of non-coding RNAs (ncRNAs), which play a major role in regulating gene expression. One emerging class of ncRNAs is the natural antisense transcripts (NATs), the RNA molecules transcribed from the opposite strand of a protein-coding gene locus. NATs are known to concordantly and discordantly regulate gene expression in both cis and trans manners at the transcriptional, post-transcriptional, translational, and epigenetic levels. Aberrant expression of NATs can therefore cause dysregulation in many biological pathways and has been observed in many genetic diseases. This review outlines the involvements and mechanisms of NATs in the pathogenesis of various diseases, with a special emphasis on neurodegenerative diseases and cancer. We also summarize recent findings on NAT knockdown and/or overexpression experiments and discuss the potential of NATs as promising targets for future gene therapies.
Item Type: Article
Uncontrolled Keywords: Antisense RNA; Cancer; Long non-coding RNA; Neurodegenerative diseases; Therapeutic targets
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 27 Aug 2022 20:10
Last Modified: 27 Aug 2022 20:10

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