Role of ZEB family members in proliferation, metastasis, and chemoresistance of prostate cancer cells: revealing signaling networks

Soleymani, Leyla and Zarrabi, Ali and Hashemi, Farid and Hashemi, Fardin and Zabolian, Amirhossein and Banihashemi, Seyed Mohammad and Moghadam, Hirin Sabouhi and Hushmandi, Kiavash and Samarghan-Dian, Saeed and Ashrafizadeh, Milad and Khan, Haroon (2021) Role of ZEB family members in proliferation, metastasis, and chemoresistance of prostate cancer cells: revealing signaling networks. Current Cancer Drug Targets, 21 (9). pp. 749-767. ISSN 1568-0096 (Print) 1873-5576 (Online)

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Prostate cancer (PCa) is one of the leading causes of death worldwide. A variety of strategies, including surgery, chemotherapy, radiotherapy, and immunotherapy, are applied for PCa treatment. PCa cells are responsive towards therapy at early stages, but they can obtain resistance in the advanced stage. Furthermore, their migratory ability is high in advanced stages. It seems that genetic and epigenetic factors play an important role in this case. Zinc finger E-box-binding home-obox (ZEB) is a family of transcription with two key members, including ZEB1 and ZEB2. ZEB family members are known due to their involvement in promoting cancer metastasis via EMT induction. Recent studies have shown their role in cancer proliferation and inducing therapy resistance. In the current review, we focus on revealing the role of ZEB1 and ZEB2 in PCa. ZEB family members are able to significantly promote the proliferation and viability of cancer cells. ZEB1 and ZEB2 enhance migration and invasion of PCa cells via EMT induction. Overexpression of ZEB1 and ZEB2 is associated with a poor prognosis of PCa. ZEB1 and ZEB2 upregulation occurs during PCa progression and can provide therapy resistance to cancer cells. PRMT1, Smad2, and non-coding RNAs can function as upstream mediators of the ZEB family. Besides, Bax, Bcl-2, MRP1, N-cadherin, and E-cadherin can be considered as downstream targets of the ZEB family in PCa.
Item Type: Article
Uncontrolled Keywords: Chemoresistance; Epithelial-to-mesenchymal transition (EMT); LncRNA; Metastasis; MicroRNA; Proliferation; Prostate cancer; Zinc finger E-box-binding homeobox (ZEB)
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 27 Aug 2022 20:34
Last Modified: 27 Aug 2022 20:34

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