Genome-wide excision repair map of cyclobutane pyrimidine dimers in arabidopsis and the roles of CSA1 and CSA2 proteins in transcription-coupled repair†

Kaya, Sezgi and Adebali, Ogün and Oztas, Onur and Sancar, Aziz (2022) Genome-wide excision repair map of cyclobutane pyrimidine dimers in arabidopsis and the roles of CSA1 and CSA2 proteins in transcription-coupled repair†. Photochemistry and Photobiology (SI), 98 (3). pp. 707-712. ISSN 0031-8655 (Print) 1751-1097 (Online)

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Abstract

Plants depend on light for energy production. However, the UV component in sunlight also inflicts DNA damage, mostly in the form of cyclobutane pyrimidine dimers (CPD) and (6-4) pyrimidine–pyrimidone photoproducts, which are mutagenic and lethal to the plant cells. These lesions are repaired by blue-light-dependent photolyases and the nucleotide excision repair enzymatic systems. Here, we characterize nucleotide excision repair in Arabidopsis thaliana genome-wide and at single nucleotide resolution with special focus on transcription-coupled repair and the role of the CSA1 and CSA2 genes/proteins in dictating the efficiency and the strand preference of repair of transcribed genes. We demonstrate that CSA1 is the dominant protein in coupling repair to transcription with minor contribution from CSA2.
Item Type: Article
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Ogün Adebali
Date Deposited: 27 Aug 2022 20:44
Last Modified: 27 Aug 2022 20:44
URI: https://research.sabanciuniv.edu/id/eprint/43839

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