Cervical cancer progression is regulated by SOX transcription factors: revealing signaling networks and therapeutic strategies

Paskeh, Mahshid Deldar Abad and Mirzaei, Sepideh and Gholami, Mohammad Hossein and Zarrabi, Ali and Zabolian, Amirhossein and Hashemi, Mehrdad and Hushmandi, Kiavash and Ashrafizadeh, Milad and Aref, Amir Reza and Samarghandian, Saeed (2021) Cervical cancer progression is regulated by SOX transcription factors: revealing signaling networks and therapeutic strategies. Biomedicine and Pharmacotherapy, 144 . ISSN 0753-3322 (Print) 1950-6007 (Online)

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Cervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy and surgery. However, cervical cancer cells demonstrate aggressive behavior in advanced phases, requiring novel strategies in their elimination. On the other hand, SOX proteins are transcription factors capable of regulating different molecular pathways and their expression varies during embryogenesis, disease development and carcinogenesis. In the present review, our aim is to reveal role of SOX transcription factors in cervical cancer. SOX transcription factors play like a double-edged sword in cancer. For instance, SOX9 possesses both tumor-suppressor and tumor-promoting role in cervical cancer. Therefore, exact role of each SOX members in cervical cancer has been discussed to direct further experiments for revealing other functions. SOX proteins can regulate proliferation and metastasis of cervical cancer cells. Furthermore, response of cervical cancer cells to chemotherapy and radiotherapy is tightly regulated by SOX transcription factors. Different downstream targets of SOX proteins such as Wnt signaling, EMT and Hedgehog have been identified. Besides, upstream mediators such as microRNAs, lncRNAs and circRNAs can regulate SOX expression in cervical cancer. In addition to pre-clinical studies, role of SOX transcription factors as prognostic and diagnostic tools in cervical cancer has been shown.
Item Type: Article
Uncontrolled Keywords: Biomarker; Cancer therapy; Cervical cancer; Chemoresistance; Non-coding RNAs; SOX transcription factor
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 28 Aug 2022 10:14
Last Modified: 28 Aug 2022 10:14
URI: https://research.sabanciuniv.edu/id/eprint/43825

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