MicroRNAs regulating SOX2 in cancer progression and therapy response

Mirzaei, Sepideh and Saebfar, Hamidreza and Gholami, Mohammad Hossein and Hashemi, Farid and Zarrabi, Ali and Zabolian, Amirhossein and Entezari, Maliheh and Hushmandi, Kiavash and Samarghandian, Saeed and Aref, Amir Reza and Ashrafizadeh, Milad and Khan, Haroon (2021) MicroRNAs regulating SOX2 in cancer progression and therapy response. Expert Reviews in Molecular Medicine, 23 . ISSN 1462-3994

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The proliferation, metastasis and therapy response of tumour cells are tightly regulated by interaction among various signalling networks. The microRNAs (miRNAs) can bind to 3′-UTR of mRNA and down-regulate expression of target gene. The miRNAs target various molecular pathways in regulating biological events such as apoptosis, differentiation, angiogenesis and migration. The aberrant expression of miRNAs occurs in cancers and they have both tumour-suppressor and tumour-promoting functions. On the contrary, SOX proteins are capable of binding to DNA and regulating gene expression. SOX2 is a well-known member of SOX family that its overexpression in different cancers to ensure progression and stemness. The present review focuses on modulatory impact of miRNAs on SOX2 in affecting growth, migration and therapy response of cancers. The lncRNAs and circRNAs can function as upstream mediators of miRNA/SOX2 axis in cancers. In addition, NF-κB, TNF-α and SOX17 are among other molecular pathways regulating miRNA/SOX2 axis in cancer. Noteworthy, anti-cancer compounds including bufalin and ovatodiolide are suggested to regulate miRNA/SOX2 axis in cancers. The translation of current findings to clinical course can pave the way to effective treatment of cancer patients and improve their prognosis.
Item Type: Article
Uncontrolled Keywords: Anti-tumour compound; biological function; cancer; chemotherapy; LncRNA; microRNA; non-coding RNA; SOX; transcription factor
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 28 Aug 2022 16:11
Last Modified: 28 Aug 2022 16:11
URI: https://research.sabanciuniv.edu/id/eprint/43802

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