Environmental exposures associated with honey bee health

Mayack, Christopher and Macherone, Anthony and Ghaffari Zaki, Asal and Filiztekin, Elif and Özkazanç, Burcu and Köprülü, Yasemin and Schick, Sassicaia J. and Eppley, Elizabeth J. and Deb, Moniher and Ambiel, Nicholas and Schafsnitz, Alexis M. and Broadrup, Robert L. (2022) Environmental exposures associated with honey bee health. Chemosphere, 286 (Part 3). ISSN 0045-6535 (Print) 1879-1298 (Online)

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Bee health is declining on a global scale, yet the exact causes and their interactions responsible for the decline remain unknown. To more objectively study bee health, recently biomarkers have been proposed as an essential tool, because they can be rapidly quantified and standardized, serving as a comparable measure across bee species and varying environments. Here, we used a systems biology approach to draw associations between endogenous and exogenous chemical profiles, with pesticide exposure, or the abundance of the 21 most common honey bee diseases. From the analysis we identified chemical biomarkers for both pesticide exposure and bee diseases along with the mechanistic biological pathways that may influence disease onset and progression. We found a total of 2352 chemical features, from 30 different hives, sampled from seven different locations. Of these, a total of 1088 significant associations were found that could serve as chemical biomarker profiles for predicting both pesticide exposure and the presence of diseases in a bee colony. In almost all cases we found novel external environmental exposures within the top seven associations with bee diseases and pesticide exposures, with the majority having previously unknown connections to bee health. We highlight the exposure-outcome paradigm and its ability to identify previously uncategorized interactions from different environmental exposures associated with bee diseases, pesticides, mechanisms, and potential synergistic interactions of these that are responsible for honey bee health decline.
Item Type: Article
Uncontrolled Keywords: Bee pathogens; Colony collapse; Exposomics; Pesticides; Systems biology; Xenobiotics
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Christopher Mayack
Date Deposited: 29 Aug 2022 15:07
Last Modified: 29 Aug 2022 15:07
URI: https://research.sabanciuniv.edu/id/eprint/43746

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