A flexible cystoscope based on hydrodynamic cavitation for tumor tissue ablation

Abbasiasl, Taher and Şutova, Hande Eda and Niazi, Soroush and Çelebi Torabfam, Gizem and Karavelioglu, Zeynep and Kirabali, Ufuk and Yilmaz, Abdurrahim and Uvet, Huseyin and Kutlu, Özlem and Ekici, Sinan and Ghorbani, Morteza and Koşar, Ali (2022) A flexible cystoscope based on hydrodynamic cavitation for tumor tissue ablation. IEEE Transactions on Biomedical Engineering, 69 (1). pp. 513-524. ISSN 0018-9294 (Print) 1558-2531 (Online)

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Objective: Hydrodynamic cavitation is characterized by the formation of bubbles inside a flow due to local reduction of pressure below the saturation vapor pressure. The resulting growth and violent collapse of bubbles lead to a huge amount of released energy. This energy can be implemented in different fields such as heat transfer enhancement, wastewater treatment and chemical reactions. In this study, a cystoscope based on small scale hydrodynamic cavitation was designed and fabricated to exploit the destructive energy of cavitation bubbles for treatment of tumor tissues. The developed device is equipped with a control system, which regulates the movement of the cystoscope in different directions. According to our experiments, the fabricated cystoscope was able to locate the target and expose cavitating flow to the target continuously and accurately. The designed cavitation probe embedded into the cystoscope caused a significant damage to prostate cancer and bladder cancer tissues within less than 15 minutes. The results of our experiments showed that the cavitation probe could be easily coupled with endoscopic devices because of its small diameter. We successfully integrated a biomedical camera, a suction tube, tendon cables, and the cavitation probe into a 6.7 mm diameter cystoscope, which could be controlled smoothly and accurately via a control system. The developed device is considered as a mechanical ablation therapy, can be a solid alternative for minimally invasive tissue ablation methods such as radiofrequency (RF) and laser ablation, and could have lower side effects compared to ultrasound therapy and cryoablation.
Item Type: Article
Uncontrolled Keywords: cavitation treatment; cystoscope; Hydrodynamic cavitation; tumor ablation
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Koşar
Date Deposited: 29 Aug 2022 16:58
Last Modified: 29 Aug 2022 16:58
URI: https://research.sabanciuniv.edu/id/eprint/43729

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