Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies

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Zha, Gao Feng and Preetham, Habbanakuppe D. and Rangappa, Shobith and Sharath Kumar, Kothanahally S. and Girish, Yarabahally R. and Rakesh, Kadalipura P. and Ashrafizadeh, Milad and Zarrabi, Ali and Rangappa, Kanchugarakoppal S. (2021) Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies. Bioorganic Chemistry, 115 . ISSN 0045-2068 (Print) 1090-2120 (Online)

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Abstract

Small molecule based inhibitors development is a growing field in medicinal chemistry. In recent years, different heterocyclic derivatives have been designed to counter the infections caused by multi-drug resistant bacteria. Indeed, small molecule inhibitors can be employed as an efficient antibacterial agents with different mechanism of action. Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to mankind due to easy transmission mode, rapid resistance development to existing antibiotics and affect difficult-to-treat skin and filmsy diseases. Benzimidazoles are a class of heterocyclic compounds which have capability to fight against MRSA. High biocompatibility of benzimidazoles, synergistic behaviour with antibiotics and their tunable physico-chemical properties attracted the researchers to develop new benzimidazole based antibacterial agents. The present review focus on recent developments of benzimidazole-hybrid molecules as anti MRSA agents and the results of in-vitro and in-vivo studies with possible mechanism of action and discussing structure–activity relationship (SAR) in different directions. Benzimdazoles act as DNA binding agents, enzyme inhibitors, anti-biofilm agents and showed synergistic effect with available antibiotics to achieve antibacterial activity against MRSA. This cumulative figures would help to design new benzimidazole-based MRSA growth inhibitors.
Item Type: Article
Uncontrolled Keywords: Antibiotics; Benzimidazole; DNA binding agents; Drug resistance; MRSA
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 30 Aug 2022 14:38
Last Modified: 30 Aug 2022 14:38
URI: https://research.sabanciuniv.edu/id/eprint/43687

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