Crosstalk between autophagy and dna repair systems

Sarıkaya, Sinem and Çakır, Hatice and Gözüaçık, Devrim and Akkoç, Yunus (2021) Crosstalk between autophagy and dna repair systems. Turkish Journal of Biology, 45 (3). pp. 235-252. ISSN 1300-0152 (Print) 1303-6092 (Online)

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Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (e.g., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity. Hence, in collaboration with DNA damage repair and response mechanisms, autophagy contributes to the maintenance of genomic stability and integrity. Yet, connections and interactions between these two systems are not fully understood. In this review article, current status of the associations and crosstalk between autophagy and DNA repair systems is documented and discussed.
Item Type: Article
Uncontrolled Keywords: Autophagy; DDR; DNA damage; DNA repair
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Devrim Gözüaçık
Date Deposited: 30 Aug 2022 16:04
Last Modified: 30 Aug 2022 16:04

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