New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities

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Ashrafizadeh, Milad and Mirzaei, Sepideh and Hashemi, Farid and Zarrabi, Ali and Zabolian, Amirhossein and Saleki, Hossein and Sharifzadeh, Seyed Omid and Soleymani, Leyla and Daneshi, Salman and Hushmandi, Kiavash and Khan, Haroon and Kumar, Alan Prem and Aref, Amir Reza and Samarghandian, Saeed (2021) New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities. Biomedicine and Pharmacotherapy, 141 . ISSN 0753-3322 (Print) 1950-6007 (Online)

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Abstract

Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells are transformed to mesenchymal cells, and at molecular level, E-cadherin undergoes down-regulation, while an increase occurs in N-cadherin and vimentin levels. Increasing evidence demonstrates role of EMT in mediating drug resistance of cancer cells. On the other hand, paclitaxel (PTX) and docetaxel (DTX) are two chemotherapeutic agents belonging to taxene family, capable of inducing cell cycle arrest in cancer cells via preventing microtubule depolymerization. Aggressive behavior of cancer cells resulted from EMT-mediated metastasis can lead to PTX and DTX resistance. Upstream mediators of EMT such as ZEB1/2, TGF-β, microRNAs, and so on are involved in regulating response of cancer cells to PTX and DTX. Tumor-suppressing factors inhibit EMT to promote PTX and DTX sensitivity of cancer cells. Furthermore, three different strategies including using anti-tumor compounds, gene therapy and delivery systems have been developed for suppressing EMT, and enhancing cytotoxicity of PTX and DTX against cancer cells that are mechanistically discussed in the current review.
Item Type: Article
Uncontrolled Keywords: Chemoresistance; Docetaxel; Drug resistance; Epithelial-to-mesenchymal transition (EMT); Metastasis; Paclitaxel
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 30 Aug 2022 18:18
Last Modified: 30 Aug 2022 18:18
URI: https://research.sabanciuniv.edu/id/eprint/43668

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