Interplay between SOX9 transcription factor and microRNAs in cancer

Ashrafizadeh, Milad and Zarrabi, Ali and Orouei, Sima and Zabolian, Amirhossein and Saleki, Hossein and Azami, Negar and Bejandi, Atefe Kazemzade and Mirzaei, Sepideh and Janaghard, Milad Nemati and Hushmandi, Kiavash and Nabavi, Noushin and Baradaran, Behzad and Kumar, Alan Prem and Makvandi, Pooyan and Samarghandian, Saeed and Khan, Haroon and Hamblin, Michael R. (2021) Interplay between SOX9 transcription factor and microRNAs in cancer. International Journal of Biological Macromolecules, 183 . pp. 681-694. ISSN 0141-8130 (Print) 1879-0003 (Online)

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SOX transcription factors are critical regulators of development, homeostasis and disease progression and their dysregulation is a common finding in various cancers. SOX9 belongs to SOXE family located on chromosome 17. MicroRNAs (miRNAs) possess the capacity of regulating different transcription factors in cancer cells by binding to 3′-UTR. Since miRNAs can affect differentiation, migration, proliferation and other physiological mechanisms, disturbances in their expression have been associated with cancer development. In this review, we evaluate the relationship between miRNAs and SOX9 in different cancers to reveal how this interaction can affect proliferation, metastasis and therapy response of cancer cells. The tumor-suppressor miRNAs can decrease the expression of SOX9 by binding to the 3′-UTR of mRNAs. Furthermore, the expression of downstream targets of SOX9, such as c-Myc, Wnt, PI3K/Akt can be affected by miRNAs. It is noteworthy that other non-coding RNAs including lncRNAs and circRNAs regulate miRNA/SOX9 expression to promote/inhibit cancer progression and malignancy. The pre-clinical findings can be applied as biomarkers for diagnosis and prognosis of cancer patients.
Item Type: Article
Uncontrolled Keywords: Cancer; Circular RNA; Long non-coding RNA; MicroRNA; SOX9; Transcription factor
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 31 Aug 2022 09:24
Last Modified: 31 Aug 2022 09:24

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