The role of SOX family transcription factors in gastric cancer

Abadi, Asal Jalal and Zarrabi, Ali and Hashemi, Farid and Zabolian, Amirhossein and Najafi, Masoud and Entezari, Maliheh and Hushmandi, Kiavash and Aref, Amir Reza and Khan, Haroon and Makvandi, Pooyan and Ashrafizaveh, Saeed and Farkhondeh, Tahereh and Ashrafizadeh, Milad and Samarghandian, Saeed and Hamblin, Michael R. (2021) The role of SOX family transcription factors in gastric cancer. International Journal of Biological Macromolecules, 180 . pp. 608-624. ISSN 0141-8130 (Print) 1879-0003 (Online)

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Gastric cancer (GC) is a leading cause of death worldwide. GC is the third-most common cause of cancer-related death after lung and colorectal cancer. It is also the fifth-most commonly diagnosed cancer. Accumulating evidence has revealed the role of signaling networks in GC progression. Identification of these molecular pathways can provide new insight into therapeutic approaches for GC. Several molecular factors involved in GC can play both onco-suppressor and oncogene roles. Sex-determining region Y (Sry)-box-containing (SOX) family members are transcription factors with a well-known role in cancer. SOX proteins can bind to DNA to regulate cellular pathways via a highly conserved domain known as high mobility group (HMG). In the present review, the roles of SOX proteins in the progression and/or inhibition of GC are discussed. The dual role of SOX proteins as tumor-promoting and tumor-suppressing factors is highlighted. SOX members can affect upstream mediators (microRNAs, long non-coding RNAs and NF-κB) and down-stream mediators (FAK, HIF-1α, CDX2 and PTEN) in GC. The possible role of anti-tumor compounds to target SOX pathway members in GC therapy is described. Moreover, SOX proteins may be used as diagnostic or prognostic biomarkers in GC.
Item Type: Article
Uncontrolled Keywords: Cancer therapy; Gastric cancer; High mobility group domain; SOX family members
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 31 Aug 2022 13:41
Last Modified: 31 Aug 2022 13:41

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