The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

Mirzaei, Sepideh and Zarrabi, Ali and Asnaf, Sholeh Etehad and Hashemi, Farid and Zabolian, Amirhossein and Hushmandi, Kiavash and Raei, Mehdi and Goharrizi, Mohammad Ali Sheikh Beig and Makvandi, Pooyan and Samarghandian, Saeed and Najafi, Masoud and Ashrafizadeh, Milad and Aref, Amir Reza and Hamblin, Michael R. (2021) The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators. Life Sciences, 268 . ISSN 0024-3205 (Print) 1879-0631 (Online)

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Cancer still remains as one of the leading causes of death worldwide. Metastasis and proliferation are abnormally increased in cancer cells that subsequently, mediate resistance of cancer cells to different therapies such as radio-, chemo- and immune-therapy. MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate expression of target genes at post-transcriptional level and capable of interaction with mRNA-coding genes. Vital biological mechanisms including apoptosis, migration and differentiation are modulated by these small molecules. MiRNAs are key players in regulating cancer proliferation and metastasis as well as cancer therapy response. MiRNAs can function as both tumor-suppressing and tumor-promoting factors. In the present review, regulatory impact of miRNA-338-3p on cancer growth and migration is discussed. This new emerging miRNA can regulate response of cancer cells to chemotherapy and radiotherapy. It seems that miRNA-338-3p has dual role in cancer chemotherapy, acting as tumor-promoting or tumor-suppressor factor. Experiments reveal anti-tumor activity of miRNA-338-3p in cancer. Hence, increasing miRNA-338-3p expression is of importance in effective cancer therapy. Long non-coding RNAs, circular RNAs and hypoxia are potential upstream mediators of miRNA-338-3p in cancer. Anti-tumor agents including baicalin and arbutin can promote expression of miRNA-338-3p in suppressing cancer progression. These topics are discussed to shed some light on function of miRNA-338-3p in cancer cells.
Item Type: Article
Uncontrolled Keywords: Cancer; Chemotherapy; Circular RNA; Long non-coding RNA; MicroRNA 338-3p
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 31 Aug 2022 17:25
Last Modified: 31 Aug 2022 17:25

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