Roles of nrf2 in gastric cancer: targeting for therapeutic strategies

Farkhondeh, Tahereh and Pourbagher-Shahri, Ali Mohammad and Azimi-Nezhad, Mohsen and Forouzanfar, Fatemeh and Brockmueller, Aranka and Ashrafizadeh, Milad and Talebi, Marjan and Shakibaei, Mehdi and Samarghandian, Saeed (2021) Roles of nrf2 in gastric cancer: targeting for therapeutic strategies. Molecules, 26 (11). ISSN 1420-3049

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Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a specific transcription factor with potent effects on the regulation of antioxidant gene expression that modulates cell hemostasis under various conditions in tissues. However, the effects of Nrf2 on gastric cancer (GC) are not fully elucidated and understood. Evidence suggests that uncontrolled Nrf2 expression and activation has been observed more frequently in malignant tumors, including GC cells, which is then associated with increased antioxidant capacity, chemoresistance, and poor clinical prognosis. Moreover, Nrf2 inhibitors and the associated modulation of tumor cell redox balance have shown that Nrf2 also has beneficial effects on the therapy of various cancers, including GC. Based on previous findings on the important role of Nrf2 in GC therapy, it is of great interest to scientists in basic and clinical tumor research that Nrf2 can be active as both an oncogene and a tumor suppressor depending on different background situations.
Item Type: Article
Uncontrolled Keywords: Antioxidants; Gastric cancer; Nrf2 inhibitor; Nrf2 pathway
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Milad Ashrafizadeh
Date Deposited: 01 Sep 2022 22:19
Last Modified: 01 Sep 2022 22:19

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