Regulation of nuclear factor-KappaB (NF-kB) signaling pathway by non-coding RNAs in cancer: inhibiting or promoting carcinogenesis?

Mirzaei, Sepideh and Zarrabi, Ali and Hashemi, Farid and Zabolian, Amirhossein and Saleki, Hossein and Ranjbar, Adnan and Seyed Saleh, Seyed Hesam and Bagherian, Morteza and Sharifzadeh, Seyed omid and Hushmandi, Kiavash and Liskova, Alena and Kubatka, Peter and Makvandi, Pooyan and Tergaonkar, Vinay and Kumar, Alan Prem and Ashrafizadeh, Milad and Sethi, Gautam (2021) Regulation of nuclear factor-KappaB (NF-kB) signaling pathway by non-coding RNAs in cancer: inhibiting or promoting carcinogenesis? Cancer Letters, 509 . pp. 63-80. ISSN 0304-3835 (Print) 1872-7980 (Online)

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The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential therapeutic target in cancer therapy. It has been well established that transcription factor NF-κB is involved in regulating physiological and pathological events including inflammation, immune response and differentiation. Increasing evidences suggest that deregulated NF-κB signaling can enhance cancer cell proliferation, metastasis and also mediate radio-as well as chemo-resistance. On the contrary, non-coding RNAs (ncRNAs) have been found to modulate NF-κB signaling pathway under different settings. MicroRNAs (miRNAs) can dually inhibit/induce NF-κB signaling thereby affecting the growth and migration of cancer cells. Furthermore, the response of cancer cells to radiotherapy and chemotherapy may also be regulated by miRNAs. Regulation of NF-κB by miRNAs may be mediated via binding to 3/-UTR region. Interestingly, anti-tumor compounds can increase the expression of tumor-suppressor miRNAs in inhibiting NF-κB activation and the progression of cancers. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) can also effectively modulate NF-κB signaling thus affecting tumorigenesis. It is noteworthy that several studies have demonstrated that lncRNAs and circRNAs can affect miRNAs in targeting NF-κB activation. They can act as competing endogenous RNA (ceRNA) thereby reducing miRNA expression to induce NF-κB activation that can in turn promote cancer progression and malignancy.
Item Type: Article
Uncontrolled Keywords: Cancer; Chemoresistance; Circular RNA; Long non-coding RNAs; MicroRNAs; Nuclear factor-kappaB (NF-κB); Radioresistance
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 03 Sep 2022 17:33
Last Modified: 03 Sep 2022 17:33

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