Venom peptides in cancer therapy: an updated review on cellular and molecular aspects

Mirzaei, Sepideh and Fekri, Hojjat Samareh and Hashemi, Farid and Hushmandi, Kiavash and Mohammadinejad, Reza and Ashrafizadeh, Milad and Zarrabi, Ali and Garg, Manoj (2021) Venom peptides in cancer therapy: an updated review on cellular and molecular aspects. Pharmacological Research, 164 . ISSN 1043-6618 (Print) 1096-1186 (Online)

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Based on the high incidence and mortality rates of cancer, its therapy remains one of the most vital challenges in the field of medicine. Consequently, enhancing the efficacy of currently applied treatments and finding novel strategies are of great importance for cancer treatment. Venoms are important sources of a variety of bioactive compounds including salts, small molecules, macromolecules, proteins, and peptides that are defined as toxins. They can exhibit different pharmacological effects, and in recent years, their anti-tumor activities have gained significant attention. Several different compounds are responsible for the anti-tumor activity of venoms, and peptides are one of them. In the present review, we discuss the possible anti-tumor activities of venom peptides by highlighting molecular pathways and mechanisms through which these molecules can act effectively. Venom peptides can induce cell death in cancer cells and can substantially enhance the efficacy of chemotherapy and radiotherapy. Also, the venom peptides can mitigate the migration of cancer cells via suppression of angiogenesis and epithelial-to-mesenchymal transition. Notably, nanoparticles have been applied in enhancing the bioavailability of venom peptides and providing targeted delivery, thereby leading to their elevated anti-tumor activity and potential application for cancer therapy.
Item Type: Article
Uncontrolled Keywords: Cancer therapy; Chemotherapy; Nanoparticle; Peptide; Regulated cell death; Venom
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 03 Sep 2022 12:56
Last Modified: 03 Sep 2022 12:56

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