Pre-clinical investigation of STAT3 pathway in bladder cancer: paving the way for clinical translation

Mirzaei, Sepideh and Gholami, Mohammad Hossein and Mahabady, Mahmood Khaksary and Nabavi, Noushin and Zabolian, Amirhossein and Banihashemi, Seyed Mohammad and Haddadi, Amirabbas and Entezari, Maliheh and Hushmandi, Kiavash and Makvandi, Pooyan and Samarghandian, Saeed and Zarrabi, Ali and Ashrafizadeh, Milad and Khan, Haroon (2021) Pre-clinical investigation of STAT3 pathway in bladder cancer: paving the way for clinical translation. Biomedicine and Pharmacotherapy, 133 . ISSN 0753-3322 (Print) 1950-6007 (Online)

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Effective cancer therapy requires identification of signaling networks and investigating their potential role in proliferation and invasion of cancer cells. Among molecular pathways, signal transducer and activator of transcription 3 (STAT3) has been of importance due to its involvement in promoting proliferation, and invasion of cancer cells, and mediating chemoresistance. In the present review, our aim is to reveal role of STAT3 pathway in bladder cancer (BC), as one of the leading causes of death worldwide. In respect to its tumor-promoting role, STAT3 is able to enhance the growth of BC cells via inhibiting apoptosis and cell cycle arrest. STAT3 also contributes to metastasis of BC cells via upregulating of MMP-2 and MMP-9 as well as genes in the EMT pathway. BC cells obtain chemoresistance via STAT3 overexpression and its inhibition paves the way for increasing efficacy of chemotherapy. Different molecular pathways such as KMT1A, EZH2, DAB2IP and non-coding RNAs including microRNAs and long non-coding RNAs can function as upstream mediators of STAT3 that are discussed in this review article.
Item Type: Article
Uncontrolled Keywords: Bladder cancer; Chemoresistance; LncRNA; Metastasis; MicroRNA; Signal transducer and activator of transcription 3 (STAT3)
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 02 Sep 2022 23:42
Last Modified: 02 Sep 2022 23:42

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