Small in size, but large in action: micrornas as potential modulators of pten in breast and lung cancers

Abadi, Asal Jalal and Zarrabi, Ali and Gholami, Mohammad Hossein and Mirzaei, Sepideh and Hashemi, Farid and Zabolian, Amirhossein and Entezari, Maliheh and Hushmandi, Kiavash and Ashrafizadeh, Milad and Khan, Haroon and Kumar, Alan Prem (2021) Small in size, but large in action: micrornas as potential modulators of pten in breast and lung cancers. Biomolecules, 11 (2). ISSN 2218-273X

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MicroRNAs (miRNAs) are well‐known regulators of biological mechanisms with a small size of 19–24 nucleotides and a single‐stranded structure. miRNA dysregulation occurs in cancer progression. miRNAs can function as tumor‐suppressing or tumor‐promoting factors in cancer via regulating molecular pathways. Breast and lung cancers are two malignant thoracic tumors in which the abnormal expression of miRNAs plays a significant role in their development. Phospha-tase and tensin homolog (PTEN) is a tumor‐suppressor factor that is capable of suppressing the growth, viability, and metastasis of cancer cells via downregulating phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt) signaling. PTEN downregulation occurs in lung and breast cancers to promote PI3K/Akt expression, leading to uncontrolled proliferation, metastasis, and their resistance to chemotherapy and radiotherapy. miRNAs as upstream mediators of PTEN can dually induce/in-hibit PTEN signaling in affecting the malignant behavior of lung and breast cancer cells. Further-more, long non‐coding RNAs and circular RNAs can regulate the miRNA/PTEN axis in lung and breast cancer cells. It seems that anti‐tumor compounds such as baicalein, propofol, and curcumin can induce PTEN upregulation by affecting miRNAs in suppressing breast and lung cancer progression. These topics are discussed in the current review with a focus on molecular pathways.
Item Type: Article
Uncontrolled Keywords: Breast cancer; Cancer therapy; Circular RNA; Long non‐coding RNA; Lung cancer; MicroRNA; PTEN
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 18 Aug 2022 17:05
Last Modified: 18 Aug 2022 17:05

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