Local carpet bombardment of immobilized cancer cells with hydrodynamic cavitation

Talebian Gevari, Moein and Aydemir, Gizem and Gharıb, Ghazaleh and Kutlu, Özlem and Uvet, Huseyin and Ghorbani, Morteza and Koşar, Ali (2021) Local carpet bombardment of immobilized cancer cells with hydrodynamic cavitation. IEEE Access, 9 . pp. 14983-14991. ISSN 2169-3536

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This study presents a method based on carpet bombardment of immobilized cells with cavitating flows. For this, immobilized cancer cell lines are exposed to micro scale cavitating flows from the tip of a micro nozzle under the effect of cavitation microbubbles. The deformation as a result of cavitation bubbles on exposed cells differs from one cell type to another. Therefore, the difference in cell deformation upon cavitation exposure (carpet bombardment) acts as a valuable indicator for cancer diagnosis. The developed system is tested on HCT-116 (Human Colorectal Carcinoma), MDA-MB-231 (Breast Adenocarcinoma), ONCO-DG-1 (Ovarian Adenocarcinoma) cell lines due to their clinical importance. The mechanical effects of cavitation are examined by considering the single-cell lysis effect (the cell membrane is ruptured, and the cell is destroyed) with the help of the Scanning Electron Microscopy (SEM) technique. Our study proposes a promising label-free method for the potential use in cancer diagnosis with cavitation bubble collapse, where microbubbles could be precisely controlled and directed to the desired locations, as well as the characterization of the biophysical properties of cancer cells. The proposed approach tool has the advantages of label-free approach, simple structure and low cost and is a substantial alternative for the existing tools.
Item Type: Article
Uncontrolled Keywords: Cancer cells; Cancer diagnosis; Cavitation bubble; Hydrodynamic cavitation; Spray structure
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Mechatronics
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ghazaleh Gharıb
Date Deposited: 19 Aug 2022 09:20
Last Modified: 19 Aug 2022 09:20
URI: https://research.sabanciuniv.edu/id/eprint/43283

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